Merck Sharp & Dohme LLC has identified compounds acting as potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) and/or 2 (HCN2) blockers reported to be useful for the ...

"Women showed higher levels of TBX3 and HCN1, which are two key genes that help drive faster heart rhythms," said Ning Li, MD, PhD, Ohio State research assistant professor and co-author of the study.

"Women showed higher levels of TBX3 and HCN1, which are two key genes that help drive faster heart rhythms," said Ning Li, MD, PhD, Ohio State research assistant professor and co-author of the study.

We would like to thank Sami Hassan for help with the 2-photon image analysis. This work was supported by grant R01NS123648 from the NIH (PI, S.A.S.). E.W.B., B.S., S ...

Published on July 31 in Nature, the study reveals how propofol inhibits the ion channel protein HCN1, which is involved in neuron activity and linked to epilepsy. The research team, led by Crina ...

In their study, published July 31 in Nature, the researchers determined the high-resolution structural details of how propofol inhibits the activity of HCN1, an ion channel protein found on many types ...

The findings are published in the journal Nature in an article titled, “Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.” “Hyperpolarization-activated cyclic ...

The general anesthetic propofol may hold the keys to developing new treatment strategies for epilepsy and other neurological disorders, according to a new study. The general anesthetic propofol ...

In their study, published July 31 in Nature, the researchers determined the high-resolution structural details of how propofol inhibits the activity of HCN1, an ion channel protein found on many ...

In their study, published July 31 in Nature, the researchers determined the high-resolution structural details of how propofol inhibits the activity of HCN1, an ion channel protein found on many ...

This is because propofol affects an ion channel called HCN1. "The HCN1 ion channel is also known as the pacemaker channel, because it's the one that determines the heart rhythm and regulates ...

After repetitive METH exposure, the excitability of LS Esr1 neurons were enhanced due to an upregulation of HCN1 cation channels. Specific knockdown of the HCN1 channels in LS Esr1 neurons allows ...