HCC827, H1975, and H358 cell lines were obtained from the American Type Culture Collection (ATCC). HCC60 cells were a kind gift of John Gordon. RPMI-7951 cells were purchased from the UCSF Cell ...

To mimic the natural development of EGFR inhibitor resistance in patients, we implanted the HCC827 control and CMTM4 KO cancer cells in animals and treated with gefitinib. Since HCC827 tumor is ...

This was highlighted by the ability of the combination to enhance the blocking of tumor growth in EGFR mutant, non-small cell lung cancer (NSCLC) cell-line derived xenograft models, including the ...

In U87MG and HCC827 cells, mTORC1 exerted a dominant role via promoting TF mRNA transcription. In EGFR-TKI-resistant H1975 and PC9 cells, it was mTORC2 that played a major role in specific repression ...

5,001 cells from 5 human lung adenocarcinoma cell lines H2228, H1975, A549, H838 and HCC827 were profiled by 10X (scRNA-seq). This dataset has bulk RNA-seq data (bulk RNA-seq). Retinas of mice at age ...

To make the rationale of our screen design more understandable to the general readers of the paper, we added some HCC827 cell characterization data before introducing our CRISPR screen in our revised ...

The IL-22 effect on the EGFR/ERK/AKT pathways in NSCLC HCC827 and PC-9 cells was determined using the CCK-8 assay, western blot, and flow cytometric analysis. A PC-9 xenograft model of IL-22 exposure ...