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eLife1mon
Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling
HCC827, H1975, and H358 cell lines were obtained from the American Type Culture Collection (ATCC). HCC60 cells were a kind gift of John Gordon. RPMI-7951 cells were purchased from the UCSF Cell ...
C&EN3mon
Serine Phosphorylation-Dependent Coregulation of Topoisomerase I by the p14ARF Tumor Suppressor†
We have used the H358 and H23 lung cancer cell lines and purified recombinant human topoisomerase I to demonstrate that the ARF/topoisomerase I interaction is regulated by topoisomerase I serine ...
SciELO3mon
PHOTOSYNTHETIC PARAMETERS AS PHYSIOLOGICAL INDICATORS OF TOLERANCE TO CADMIUM STRESS IN SUNFLOWER GENOTYPES
The second experiment was carried out using seeds of one Cd-tolerant (H358) and one Cd-sensitive (AG960) sunflower genotype. Growth conditions and Cd concentrations were the same as those used in the ...
thegoldknight4mon
Oscars 2025: 97th Academy Awards nominations
Nominations for the 97th Academy Awards were unveiled Tuesday morning in global live stream by The Academy. Nominations for the 97th Academy Awards are being unveiled Tuesday morning in a global live ...
C&EN8mon
Modular Semisynthetic Approach to Generate T Cell-Dependent Bispecific Constructs from Recombinant IgG1 Antibodies
Get article recommendations from ACS based on references in your Mendeley library. Pair your accounts. Export articles to Mendeley Get article recommendations from ACS based on references in your ...
ahajournals.org10mon
Dapagliflozin Enhances Arterial and Venous Compliance During Exercise in Heart Failure With Preserved Ejection Fraction: Insights From the CAMEO-DAPA Trial
Systemic arterial compliance and venous capacitance are typically impaired in patients with heart failure with preserved ejection fraction (HFpEF), contributing to hemodynamic congestion with stress.
ascopubs.org1y
Simultaneous detection of tumor-derived mutations in DNA and RNA extracted from a single circulating tumor cell based on droplet digital polymerase chain reaction.
Cancer associated macrophages in blood correlates with poor outcomes in patients with clinically resectable disease in gastrointestinal cancers. This is an ASCO Meeting Abstract from the 2024 ASCO ...
ascopubs.org1y
Characterization of BTX-10908, a first-in-class, orally bioavailable SOS1 bifunctional degrader for the treatment of KRAS- and RTK-driven cancers.
Navigating the clinical trial maze: Identifying barriers to enrollment among patients with advanced cancer in a community-academic partnership. Synergistic cytotoxicity of histone deacetylase, ...
The Lancet1y
Tumoral and stromal hMENA isoforms impact tertiary lymphoid structure localization in lung cancer and predict immune checkpoint blockade response in patients with cancer
dBiostatistics and Scientific Direction, IRCCS-Regina Elena National Cancer Institute, Via E. Chianesi 53, 00144, Rome, Italy ePathology Unit, IRCCS-Regina Elena National Cancer Institute, Via E.
Cancer Research2y
American Association for Cancer Research
A novel lead series was identified with robust tumor cell growth inhibition, exemplified with the TEB-17112 lead candidate, having IC50 of inhibition against multiple KRAS-altered cell lines: NCI-H358 ...
Cancer Research2y
Abstract 5268: Drug screening of non-small cell lung cancer patient-derived organoids in a microwell platform
Seeded cells migrate and form spheroids in each microwell. NSCLC spheroids of H358 (KRASG12C), A549 (KRASG12S) and PDOs CK7152 (KRASG12C, obtained from NCI PDMR) were cultured in arrays and treated by ...