Logistic regression was found to have the highest accuracy of 65% among all the ML models. Furthermore, MYC, POLR2A, ALB, MTOR, H2AFX, SMARCA4, PAX6, GATA3 and MDM2 were identified as the hub genes in ...

Cardiac myocyte–specific deletion of either glycogen synthase kinase (GSK)-3α and GSK-3β leads to cardiac protection after myocardial infarction, suggesting that deletion of both isoforms may provide ...

This study demonstrates that NGS-MSI is noninferior to IHC-MMR and can identify MSI-H tumors that IHC-MMR is unable to detect and conversely IHC-MMR can identify MMRd tumors that NGS-MSI misses. This ...

This important work advances our understanding of CHMP5's role in regulating osteogenesis through its impact on cellular senescence. The evidence supporting the conclusion is mostly convincing, ...

Nuclear expression of Ku86, but not of DNA-PKcs, phospho-DNA-PKcs, Ku70 or γ-H2AFX, was reduced in bronchiolar epithelial cells from patients with COPD compared with normal smokers and non-smokers ...

Department of Biochemistry, University of Toronto, Toronto, ON M56 1A8, Canada Canada Research Chairs Program, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada Article ...

Non-small cell lung cancer (NSCLC) is a malignant tumor with a high clinical incidence and frequent cause of cancer death (1, 2). Currently, the main methods for treating NSCLC include surgery, ...

Opportunistic cervical cancer screening for elderly women without standardized screening. This is an ASCO Meeting Abstract from the 2022 ASCO Annual Meeting I. This abstract does not include a full ...

There were 7 overlapped miRNA-mRNA pairs identified during osteogenic differentiation of MC3T3-E1 cells, including mmu-miR-204-5p-Arhgap11a, mmu-miR-211-5p-Arhgap11a, mmu-miR-24-3p-H2afx, ...