A Cancer Gene Therapy study reveals that MEOX2 promotes lung cancer progression while SMARCB1 acts as a tumor suppressor, ...

In resistant cell lines (H1975 and H1650), the efficacy of cetuximab was increased when combined with CYT387, whereas CYT387 alone in low doses exhibited little effect on NSCLC cell proliferation. In ...

In Vitro Efficacy: JSKN021 significantly inhibited cancer cell growth in multiple cell lines expressing EGFR, HER3, or both (e.g., HCC827, MDA-MB-468, A431, NCI-H1975). In Vivo Efficacy: In multiple ...

Quality control was verified by Radio-HPLC. In micro-PET/CT imaging, 18 F-LF50 probe were researched in bearing HCC827 xenografts mouse models (Del19), bearing H1975 xenografts mouse models ...

Cell Lines, Lentiviral-Mediated COL8A1 Knockdown and COL8A1 Overexpression A549, H1299 and H1975 NSCLC cell lines were purchased from ATCC and then cultured in RPMI 1640 (Hyclone, USA), supplemented ...

Center for Mitochondrial Biology and Medicine & Douglas C. Wallace Institute for Mitochondrial and Epigenetic Information Sciences, The Key Laboratory of Biomedical Information Engineering of Ministry ...

The expression levels of three selected differential proteins, CAT, HMOX1, and SCD were verified. This study reveals the potential targets of CTS in H1975 cells, providing evidence of CTS as a ...

In the preclinical study, researchers developed an osimertinib-resistant H1975-OsiR isogenic cell line through continuous exposure to osimertinib. Xenograft tumors from both H1975-parental and ...

Furthermore, this Fc domain of ACE2‐Fc was shown to activate NK cell degranulation after co‐incubation with Spike‐expressing H1975 cells. These promising characteristics potentiate the therapeutic ...

To seek critical nodes in the RAS signaling pathway, we extended our previous study using the LUAD cell line we previously characterized (PC9, bearing the EGFR mutation, E746_A750del) and two ...