Why We Love It: This formula features peptides that work similarly to TGF—the growth factor best for helping improve deeper wrinkles, sagging, and sun damage— as well as thymosin beta 4, a ...

Potential Positives. Findings highlight the potential of IO Biotech's novel TGF-β-directed peptide vaccine, IO170, to significantly reduce tumor growth in pancreatic adenocarcinoma and prostate ...

A big reason for this was the softness, or "floppiness," of GRB2 and SOS1, making them difficult to study with tools like X-ray crystallography and cryo-transmission electron microscopy.

Tokyo, Japan – Researchers from Tokyo Metropolitan University have uncovered new insights into how the proteins GRB2 and SOS1 in cells pass signals from membrane receptors to nuclei. They used ...

When it comes to cancer metastasis, it takes two to tango. That was one of the key findings of a new study led by researchers at Memorial Sloan Kettering Cancer Center (MSK): The TGF-beta and RAS ...

Background: Tumor Growth Factor β (TGF-β) plays an important role in cancer development. There are three TGF-β isoforms in human: β1, β2, β3. OT-101- an antisense against TGF-β2 – has been shown to be ...

Background: TGF-β signaling pathway activation inhibits anti-tumor response, promoting tumor progression and metastasis. GFH018, a small molecule inhibiting TGF-βRI kinase, blocks TGF-β signaling ...

TGFBI was also found to mediate the pro-scarring effects of transforming growth factor-beta (TGF-beta) — a protein that plays a key role in IPF — through the regulation of GPSM2 and Snail, two ...

To translate these findings to the clinic, the Baylor team tested fresolimumab, a monoclonal antibody therapy that neutralizes TGF-β in a Phase 1 clinical trial conducted at BBDC sites at Baylor and ...

The functions of TGF-β are cell type- and context-dependent. Increasing evidence suggests that TGF-β signaling acts like a double-edged sword in tumor progression (Bierie and Moses, 2006; Massagué, ...

Gab2 (Grb2-associated binder2) silencing inhibits TAK1 (transforming growth factor beta-activated kinase 1) phosphorylation and ubiquitination, and TAK1 inhibition suppresses Gab2-dependent ...