A steam engine in Plymouth has been restored in memory of an 11 year old boy who died of a rare form of cancer, and will raise money for the hospice where he died.

Meanwhile, for GATA2 deficiency, which carries a predisposition to MDS and acute myeloid leukemia (AML), CBC is recommended every 3-4 months with BMA/Bx and a somatic gene panel recommended every ...

Inherited germline GATA2 coding sequence variants cause variably penetrant GATA2 deficiency syndrome in the adult or in pediatric contexts characterized by predisposition to myelodysplastic syndrome ...

Cutaneous infections, panniculitis, and lymphoedema in the setting of cytopenia, especially monocytopenia, should trigger suspicion of GATA2 deficiency. Lymphoedema associated with GATA2 deficiency is ...

The GATA2 gene is located on chromosome 3q21.2. To date, more than 150 pathogenic or likely pathogenic germline variants are reported, affecting nearly 500 individuals (11, 16, 19, 20).Null mutations ...

Jasper Therapeutics Initiates New Clinical Trial with National Cancer Institute to Evaluate JSP191 in GATA2-related Myelodysplastic Syndromes . September 08, 2021 08:30 AM Eastern Daylight Time.

GATA2-spectrum disorders (GATA2 deficiency syndrome) Heterozygous germline mutation in GATA2; haploinsufficiency resulting in a protean disorder that may include abnormalities of hematopoiesis, ...

Germline Genetic Predisposition to Myeloid Neoplasia From GATA2 Gene Mutations: Lessons Learned From Two Cases Iman Abou Dalle , Sarah A. Bannon , Keyur P. Patel , Mark J. Routbort , Jorge E. Cortes , ...

We next evaluated the functional consequences of the removal of Runx1/Gata2 or Erg/Fli1 from the 8TFs construct. We hypothesized that removing Runx1 and Gata2 would enhance the endothelial cell fate, ...