DB-OTO, which Regeneron obtained from the 2023 acquisition of Decibel Therapeutics for $109 million, works by delivering a ...

SENS-501 (OTOF-GT) currently being developed in a Phase 1/2 clinical trial, targets deafness caused by mutations of the gene encoding for otoferlin and GJB2-GT targets hearing loss related to ...

SENS-501 (OTOF-GT) currently being developed in a Phase 1/2 clinical trial, targets deafness caused by mutations of the gene encoding for otoferlin and GJB2-GT targets hearing loss related to ...

Get Instant Summarized Text (Gist) A novel adeno-associated virus (AAV) vector-mediated genome editing approach has been developed to repair the R75W mutation in the GJB2 gene, which causes ...

Scientists from Juntendo University and The University of Tokyo have created an adeno-associated virus (AAV)-based genome editing approach to treat genetic hearing loss caused by the GJB2 R75W ...

GJB2 is the gene responsible for approximately half of all cases of hereditary hearing loss. Connexin 26 (CX26), which is encoded by GJB2, helps in the formation of intercellular gap junctions ...

GJB2-GT: Gene therapy program to restore hearing in GJB2 patients Sensorion's AAV-based GJB2 gene therapy program developed in collaboration with the Institut Pasteur, has the potential to address ...

The most commonly implicated gene in nonsyndromic hearing loss is GJB2, which encodes connexin 26, a protein essential for normal inner ear function. Mutations in this gene can lead to varying ...

Mutations in the GJB2 gene are the cause of an important number of cases of non-syndromic recessive deafness but are not as common in non-syndromic dominant deafness cases. We describe here a new ...

Similarly, the universities portfolio in Preclinical comprises 1 molecule. Gap Junction Beta 2 Protein (GJB2), also known as connexin 26, is a member of the connexin family of proteins that form gap ...

01.DATA - vcf.gz files that has been annotated with VEP (ensembl-vep :106.1) and its index. GJB2.vep_control_split_csq.vcf.gz was downloaded and intercepted from 1000 Genomes, while ...

The newly developed label free silver nanoparticle SERS sensor capable of detecting DNA of GJB2 genes causing hearing loss. Credit: International Journal of Biological Macromolecules (2024).