The researchers discovered a distinct link between low FOXP3 expression and more severe clinical presentations. Patients in the low FOXP3 group were more likely to exhibit advanced disease stages, ...

A team of scientists from the Perelman School of Medicine at the University of Pennsylvania and Aum Biotech LLC have described the development of a novel cancer immunotherapy designed to target ...

Researchers from Osaka University found that the transcription factor Ikaros associates with Foxp3 via its exon 5, and that this interaction inhibits the expression of target genes such as Ifng in ...

Many of these dysregulated genes are Foxp3 targets, and we show that Foxp3 cooperates with Ikaros to occupy the majority of Foxp3 binding sites in Treg. Mice with Treg lineage-specific loss of Ikaros ...

Foxp3 was playing a far more fundamental and extensive role in regulatory T cell development than expected. Previous research pointed to two Foxp3 proteins pairing up in a special way to create ...

Quell Therapeutics and AstraZeneca have entered a collaboration, exclusive option and licence deal for the development, manufacturing and commercialisation of engineered T-regulator (Treg) cell ...

DDX39B is a helicase with known functions in mRNA splicing and nuclear export. This important study provides convincing evidence that DDBX39B regulates Foxp3, a lineage marker for T-regulatory cells ...

We describe a new role for Mg in suppressing arthritis, in expanding Foxp3+ T reg cells and in the production of IL-10, and show that these effects are mediated by the intestinal microbiome. Our ...

Stable Foxp3 expression is essential for Treg cell function because Foxp3 directly regulates the gene expression that organizes the Treg cell signature . “Fragile” Treg cells, which have reduced Foxp3 ...