The physical interactome of a protein can be altered upon perturbation, modulating cell physiology and contributing to disease. Identifying interactome differences of normal and disease states of ...

Uni-FEP-Benchmarks is a benchmark dataset designed to systematically evaluate Uni-FEP, a free energy perturbation (FEP) method for accurate and efficient binding free energy calculations. This ...

Uni-FEP-Benchmarks is a benchmark dataset designed to systematically evaluate Uni-FEP, a free energy perturbation (FEP) method for accurate and efficient binding free energy calculations. This ...

A set of 16 BRGs, including MMP1, ACOT7, AGPAT5, FLAD1, PDSS1, HSPD1, FKBP1A, AKR1B10, HDAC1, HDAC2, MAPT, ACADS, ACAT1, ACSL6, PDE2A, and PON1, were identified. Kaplan–Meier survival analysis showed ...

For this purpose, a stable SIMPL2 cell line of FRB-β10-IN/IC- β9-FKBP1A and a stable NanoBiT cell line of FRB-LgBiT/FKBP1A-SmBiT were created using CRISPR-Cas9. For the assay, the stable cells were ...

Regeneron Pharmaceuticals Inc. has patented rapamycin analogues acting as peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP12; Rotamase) ligands reported to be useful for the treatment of Alzheimer’s ...

The key targets in the Liver Transplant Rejection pipeline products market include T Cell Surface Antigen CD2, Programmed Cell Death 1 Ligand 1, and Peptidyl Prolyl Cis Trans Isomerase FKBP1A. The key ...

FKBP1A is an immunophilin involved in immunosuppression that can interact with and inhibit TGFBR1, which, in turn, promotes mesenchymal-to-epithelial transition (MET) and improves reprogramming ...