Metformin, a drug used as a first-line treatment for type 2 diabetes, has been associated with a 30% lower risk of death, ...

Researchers from Osaka University find that the longevity-associated factor Foxo3 mediates erroneous cell elimination during vertebrate development, with important implications for both precise ...

Notably, they found that the protein Foxo3 may be a universal marker of cell competition in zebrafish and mice. These findings have important implications for congenital disorders, cancer ...

This discovery led to the identification of Foxo3, a protein previously linked to longevity, as a mediator of cell competition. Cell competition can eliminate various unfit cells, including those ...

Cologne, Germany, 4 December 2024 - Refoxy Pharmaceuticals GmbH is a preclinical biotech company developing small molecule activators of the FOXO3 transcription factor for the treatment of age-related ...

Dr Mosley said: "Professor Wilcox thinks going on a low-calorie diet that’s rich in vegetables and foods containing antioxidants helps activate genes such as FoxO3 that play a part in healthy ...

1 Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China 2 Institute of Aging and Age-Related Disease Research, Central South University, Changsha, China ...

Circular RNA Forkhead box O3 (circ-Foxo3, hsa_circ_0006404) is encoded by the human FOXO3 gene and is one of the most studied circular RNAs acting as a sponge for potential microRNAs (miRNAs) (Du et ...

“We noticed a transcription factor called FoxO3. Cells from patients with pulmonary fibrosis contained less of this protein than cells from healthy controls. The results were even clearer once we ...