Furthermore, through the analysis of single-cell sequencing data and molecular experiments, we revealed that high glucose suppresses foxo1a expression and increases the expression of its downstream ...

Importantly, the authors further confirmed the effects of monosaccharides on inducing excessive angiogenesis were mediated by the foxo1a-marcksl1a pathway. These results demonstrate the potentially ...

Selenoprotein P is a hepatokine with antioxidative properties that eliminate a physiologic burst of reactive oxygen species required for intracellular signal transduction. Serum levels of ...

1 Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China 2 Department of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for ...

Genetic analysis has been successful in identifying causative mutations for individual cardiovascular risk factors. Success has been more limited in mapping susceptibility genes for clusters of ...

FoxO1a, a direct Akt substrate, is dephosphorylated upon NGF withdrawal and consequently undergoes nuclear translocation and activates pro-apoptotic genes. We find that Trib3 is required for ...

aRMS harbors a translocation-mediated PAX3:FOXO1A fusion gene and has an extremely poor prognosis. MATERIALS AND METHODS: Primary murine aRMS cultures were obtained from the Myf6Cre, Pax3:Foxo1a, p53 ...

Figure 1: CEBPB cooperatively regulates gene expression with FOXO1A in placental mammals. These results suggest that the cooperative CEBPB/FOXO1A interaction evolved in placental mammals.

Here, we investigate the evolution of a protein-protein interaction (PPI) between Homeobox A11 (HoxA11) and Forkhead box 01A (Foxo1a). Using extant and “resurrected” ancestral proteins, we show that ...

Notice is hereby given that on May 16, 2011, the Department of Health and Human Services (HHS) Debarring Official, on behalf of the Secretary of HHS, issued a final notice of debarment based on the ...