Forkhead box protein L2 (FOXL2) is a protein involved in ovary development and maintenance, among other functions. Mutations in its gene are involved in ovarian failure and granulosa cell tumors, ...

Scientists at the Research Institute of the McGill University Health Centre (RI-MUHC) recently discovered six new genes—FOXL2, MAJIN, KASH5, SYCP2, HFM1 and MEIOB—that cause recurrent ...

Most studies on molecular mechanisms focus on the male pathway because female development has traditionally been considered the default pathway. Challenging this traditional assumption, we found that ...

Background: Granulosa-cell tumors (GCT) of the ovary are a rare entity characterized by presenting a punctual mutation at the FOXL2 gene 402C→G (C134W) in most cases. Such mutation is responsible for ...

Previous experiments have shown that removing a gene called Foxl2 in female (XX) mice at different points in development has different effects depending on the timing. If removed from embryos ...

Previous experiments have shown that removing a gene called Foxl2 in female (XX) mice at different points in development has different effects depending on the timing. If removed from embryos ...

The following is a summary of “Expanded phenotypic spectrum of FOXL2 Variant c.672_701dup revealed by whole-exome sequencing in a rare blepharophimosis, ptosis, and epicanthus inversus syndrome family ...

Meanwhile, another two genes reported in non-Europeans, EDAR and FOXL2, had no apparent effect in Europeans. "By having demonstrated that eyebrow variation is determined by both shared and distinct ...

However, the researchers note that, back in 2007, a different team found expression of ATF3 is regulated by another transcription factor, FOXL2, mutations of which “are known to lead to alterati ...

Background: Nearly all adult-type granulosa cell tumors of the ovary (aGCTs) carry the same oncogenic mutation affecting the second winged helix domain of the Forkhead family transcription factor ...