Quralis Corp. has entered into a number of agreements with the aim of advancing the treatment of fragile X syndrome, a genetic condition caused by a mutation of a single gene – fragile X messenger ...

Key genetic contributors include single-gene mutations in SHANK3, MECP2, FMR1, and PTEN, which can cause autism-related syndromes like fragile X or Phelan-McDermid syndrome. Copy number variations ...

This study presents valuable findings by using Fmr1 knockout mice as a model to investigate the role of Fmr1 in sleep regulation. These mice exhibited clear evidence of sleep and circadian ...

They might also go into menopause earlier than usual. Fragile X syndrome is passed down in families through a mutation in the FMR1 gene. The FMR1 gene, which is on the X chromosome, makes a ...

We need this to change. Now." For individuals concerned about potentially carrying the gene, the advice from the Fragile X Society is to undergo a Fragile X (FMR1) DNA test. One case study ...

“Fragile X syndrome is caused by a change in the FMR1 gene, and the FMR1 gene is located on the X chromosome,” explains Richardson. “This abnormal gene, which can be passed from generation ...

We need this to change. Now." For those worried they may have inherited the gene, the Fragile X Society advises seeking out a Fragile X (FMR1) DNA test. Alex McQuade, a 41-year-old mother ...

These issues arise from the silencing of the Fmr1 gene, leading to impaired BK channel function, which is essential for neuron communication. Spinogenix’s SPG601 is a novel small molecule BK channel ...

This Research Topic aims at gathering Proceedings of the Fourth International Conference of FMR1 Premutation: Basic Mechanisms, Clinical Involvement and Therapy. This conference has become a major ...

In October 2023, the Company presented results from a MM-402 nonclinical study in a model of ASD, titled “MM-402 demonstrates better efficacy than S(+)-3,4-MDMA or (±)-3,4-MDMA in Fmr1 knockout ...

Fragile X syndrome is a genetic disorder caused by a mutation in a gene that lies at the tip of the X chromosome. It is linked to autism spectrum disorders. People with fragile X experience a range of ...

We surmised that RNA mis-splicing might be prevalent in human FXS patient tissues (blood and brain) and thus isolated leukocytes from 29 FXS males and 13 typically developing (TD) age-matched males ...