KYMR jumps after KT-621 phase I data beats expectations, matching or topping Dupixent on key biomarkers in Th2 diseases.

and Eotaxin-3 respectively, two signaling molecules that play an active role in recruiting immune cells. Dupilumab, which is taken by more than one million patients, is approved for both eczema ...

Eotaxin-3, a highly specific downstream cytokine of the IL-4/IL-13 pathway, was also measured. Eotaxin-3 reduction was observed for all KT-621 dose groups with a median reduction of 63% at Day 14.

Complete STAT6 degradation achieved in both blood and skin at all MAD doses ≥50 mg KT-621 impact on Th2 biomarkers in line or superior to dupilumab with median TARC reduction up to 37% and median ...

Oesophageal expression of eotaxin-3 stimulated by Th2 cytokines might contribute to oesophageal eosinophilia in EoE. Th2 cytokine effects on the oesophagus in GORD are not known. The objective of the ...

Eotaxin-3/C-C motif chemokine ligand 26 (CCL26), a member of the CC family of chemokines, exerts its chemotactic activity on eosinophils and basophils as target cells [5]. Its production is mediated ...

nasal polyps illustration Researchers examined the effect of 5-aminoimidazole4-carboxamide ribonucleotide on thymic stromal lymphopoietin and eotaxin-3 production in nasal polyp epithelial cells.

In addition, we revealed the involvement of interleukin-5 (IL-5), thymus- and activation-regulated chemokine/C-C motif chemokine ligand-17 (TARC/CCL-17), eotaxin-3/CCL-26, tumor necrosis factor-α (TNF ...