In many kinases the on-state and the off-state have very different confirmations, but that it not the case for ERK2 (Zhang et al., 1994; Canagarajah et al., 1997). Indeed, the difference is so subtle ...

The authors reveal functional redundancy and shared function for Erk1 and Erk2 in determining medial ganglionic eminence derived glial number, and exclude a role for Erk1 and Erk2 in the regulation of ...

ERK2 is closely related to the occurrence of neutrophil inflammation [5]. However, the specific molecular machinery is not fully understood [6] [7]. Given this, this study aimed to explore the ...

GAPDH was used as an internal control. qPCR was performed as mentioned previously. In addition, the expression of proteins AKT, p-AKT, ERK2, p-ERK2, and Ras (G12D) was determined in all three groups.

However, the mechanisms by which ERK controls the EMT program are not well understood. Through an analysis of the global changes of gene expression mediated by ERK2, we identified the transcription ...

More than one isoform has been described at each level of the cascade. In this review we devoted our attention to ERK1 and ERK2, which are the effector kinases of the pathway. Whether ERK1 and ERK2 ...

PASMCs under hypoxia and hypercapnia condition and intended to explore the mechanism of R g1 which had effect on PASMCs through observing the expression of p-ERK protein and the expression of ERK1 ...

Flow cytometry (bottom) showed that ERK1 and ERK2 phosphorylation was also not reduced in CD103+ cells. Our experiments showed an unanticipated uncoupling between the decrease in BRAF activity ...

Here we present three structures of PEA-15 bound to different phosphorylated states of ERK2, which provide the first structural insight into an ERK2 regulator complex. Our study reveals how PEA-15 ...

Find more information on the Altmetric Attention Score and how the score is calculated. The MAP kinase ERK2 (ERK2, extracellular signal-regulated kinase 2) is regulated by numerous phosphatases that ...

We performed knockdown experiments of the two isoforms of Erk in these cells and measured the total Erk level as well as the levels of phosphorylated Erk1 and Erk2. As a first result, this analysis ...