Congenital heart disease is a leading cause of death in newborns, yet many of its molecular mechanisms remain unknown. Both maternal obesity and diabetes increase the risk of congenital heart disease ...

Eukaryotic Initiation Factor 4 (eIF4) is a group of factors that activates mRNA for translation and recruit 43S preinitiation complex (PIC) to the mRNA 5′ end, forming the 48S PIC. The eIF4 factors ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. This study explores the mechanisms of ribosome ...

Cerebral vascular malformations (CCMs) are primarily found within the brain, where they result in increased risk for stroke, seizures, and focal neurological deficits. The unique feature of the brain ...

Confirmation was obtained by quantitative real-time reverse transcription-PCR. Of the genes involved in the activation of mRNA for cap-dependent translation (eIF4 factors), eIF4A, eIF4G1 and eIF4B ...

The signaling cascades activate translation by stimulating the eIF4 factors already resident in the mRNP and thereby disrupt the repressive effects of 4EIPs and RBPs, and activate GLD-2 to elongate ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. GBM patient‐conditioned medium increases mTOR ...

aLaboratory for Molecular Psychiatry, RIKEN Center for Brain Science, Saitama, Japan bSupport Unit for Bio-Material Analysis, Research Resources Division, RIKEN Center for Brain Science, Saitama, ...

This represents a promising resource for genetic resistance against viruses. Taking the eIF4 factors as an example, this review presents some possible approaches to turn our knowledge on virus-host ...