The final event and winner selection will take place in September at the Porsche Experience Centre Toronto ...

To investigate E2F1's role in cancer progression, Brigitte M. Pützer, M.D., Ph.D., of the department of vectorology and experimental gene therapy at the University Rostock in Germany, and ...

This work shows that KDM2A demethylates trimethylated histone H3 lysine 36 (H3K36me3) and cooperates with the transcription factor E2F1 and its co-factor HCFC1 during the transition from mitosis to ...

Figure 2B is corrected. Corresponding source data is published. Figure 3B Ac. Casp3, E2f1+/+ & E2f1-/-, Tg panels are retracted. Figure 3B TUNEL, E2f1+/+ & E2f1-/-, Tg panels are retracted. Figure 3B ...

We and others identified retinoblastoma features that suggested that the tumors originate in long- and medium-wavelength cone precursors, and we discovered features of these cone precursors that ...

E2F1 (E2F transcription factor 1) inhibitor HLM006474 was used in EC-specific Sox17 mice. SOX17 expression was downregulated in the lung and pulmonary ECs from patients with idiopathic PAH. Mice with ...

The activity of E2F1, the archetypal and most heavily studied E2F family member, is tightly controlled by the DNA damage checkpoints to modulate cell cycle progression and initiate programmed cell ...

Here, with mechanistic exploration of a next-generation chemical degrader of BET proteins (dBET6), we reveal a profound and consistent impact of BET proteins on E2F1- dependent transcriptional program ...

The transcription factor E2F1 is a central player involved in cell cycle progression, DNA-damage response, and apoptosis. Its crucial role in the control of cell fate has been extensively studied and ...

Hyperactivation of the transcriptional factor E2F1 occurs frequently in human cancers and contributes to malignant progression. E2F1 activity is regulated by proteolysis mediated by the ubiquitin ...