The authors aimed to identify which regions of DVL2 contribute to its endogenous/basal clustering, as well as the relevance of such domains to condensate/phase separation and WNT activation. Strengths ...

In the cochlea, Wnt5a and Wnt7b are redundantly required for cochlear duct coiling and elongation, HC planar polarity, and asymmetric localization of core PCP proteins Fzd6 and Dvl2. Mechanistically, ...

The study "Endogenous oligomer formation underlies DVL2 condensates and promotes Wnt/β-catenin signaling" by Senem Ntourmas et al. contributes to the understanding of phase separation in Dishevelled ...

We thank K. Löffler and M. Weidmann for their technical support. We thank F. Heigwer, L. Wolf, F. Port, and all members of the M.B. laboratory for helpful discussions. We thank the teams of the Nikon ...

There was a direct interaction between WWP1 and DVL2 (disheveled segment polarity protein 2). DVL2 was stabilized by WWP1-mediated K27-linked polyubiquitination. The role of WWP1 in pressure ...

A recent genetic study at the University of Helsinki provides new information on the occurrence of a DVL2 gene defect associated with a screw tail and its relevance to canine constitution and health.

A recent genetic study provides new information on the occurrence of a DVL2 gene defect associated with a screw tail and its relevance to canine constitution and health. The variant was found in ...

Furthermore, we found that silencing of KIF3B decreased the expression of Dvl2, phospho-GSK-3β, total and nucleus β-catenin, then subsequent down-regulation of Wnt/β-catenin signaling target genes ...

We further identified that disheveled-2 (DVL2) was crucial for FOXM1-induced Snail expression, metastasis and chemoresistance. Furthermore, FOXM1 bound to DVL2, and enhanced nuclear translocation of ...

The ash contents vary from 4.23% (cultivar DVA2) to 8.32% (cultivar DVL2). For total sugars, the values are between 53.63% (cultivar DVL2) and 57.99% (cultivars DVL12 and KA0303). The fiber contents ...

The ash contents vary from 4.23% (cultivar DVA2) to 8.32% (cultivar DVL2). For total sugars, the values are between 53.63% (cultivar DVL2) and 57.99% (cultivars DVL12 and KA0303). The fiber contents ...