There is no approved drug therapy and the major causative mechanisms are not fully understood. Dual specificity phosphatase 22 (DUSP22) is a pleiotropic signaling molecule that plays important roles ...

Photo courtesy of the National Health Research Institute A study led by institute associate investigator Lin Wen-jye (林文傑) discovered via bioinformatics that the expression of the DUSP22 gene is ...

No statistically significant variants were found in LN-vs-NLN associations, but heterogeneity tests revealed loci including ELF1, OX40, DUSP22, and TPCN2. Investigators identified distinct genetic ...

A limitation of current antiplatelet therapies is their inability to separate thrombotic events from bleeding occurrences. A better understanding of the molecular mechanisms leading to platelet ...

1 Graduate School of Medicine, Kyoto University, Department of Clinical Immunology and Rheumatology, Kyoto, Japan 2 Graduate School of Medicine, Kyoto University, Department of Advanced Medicine for ...

A prime example is the discovery of DUSP22-IRF4 or TP63 rearrangements in ALK-negative Anaplastic large cell lymphoma which portend favorable and poor risk respectively. The use of targeted therapy ...

The ECHELON-2 study compared brentuximab vedotin plus cyclophosphamide, doxorubicin, and prednisone chemotherapy with the standard-of-care cyclophosphamide, doxorubicin, vincristine, and prednisone ...