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New microscope can image, at once, the full 3D orientation and position of molecules in cells
A hybrid microscope allows scientists to simultaneously image the full 3D orientation and position of an ensemble of molecules, such as labeled proteins inside cells. The microscope combines polarized ...
3D structure of the social amoeba genome sheds light on the transition to multicellularity
Each cell of the human body contains two meters of DNA. The whole secret lies in the intricate three-dimensional arrangement that allows DNA strands to be efficiently organized and compacted within ...
In vitro reconstitution of meiotic DNA double-strand breaks: A long-standing challenge solved
In a study published in Nature, researchers report the successful in vitro reconstitution of meiotic DNA double-strand breaks ...
eLife2d
Force transmission through the inner kinetochore is enhanced by centromeric DNA sequences
This valuable work extends previous studies to convincingly show that the centromere-histone core contributes to force transduction through the kinetochore. The centromere mainly strengthens one of ...