The Double Helix” paints Watson and Crick as lone pioneers while downplaying the contributions of others, most notably of ...

Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, providing insights into its DNA recognition and cleavage mechanisms.

The interplay of mono- and polyubiquitylation together with sumoylation of PCNA in response to DNA damage provides a glimpse of how replication-fork structure and activity is controlled by a ...

Broken replication forks with single double-stranded ... copy number requires a change in chromosome structure, joining two formerly separated DNA sequences. These junctions give important ...

To address this possibility, we measured the effect of IBC and BKC on replication fork progression in MCF-7 and BJ cells by using a DNA fiber spreading assay. Briefly, the cells were exposed to one or ...

"This has been a longstanding biochemical question because the machinery responsible for replication actually destroys all the DNA structure that exists, and that structure must be faithfully ...

Of particular importance, Neandertal DNA also seems to influence the structure and function of the cerebellum. Although most neuroscientists have tended to think of this brain region as ...

in which forks reverse their direction to form a Holliday junction-like structure. The reversed replication forks are protected from nuclease degradation by DNA damage repair proteins, such as BRCA1, ...

DNA lesions can alter the primary structure of the double helix thereby affecting ... ATR is mainly induced upon DNA single strand breaks (SSBs) originated by replication fork stalling or as result of ...