Ancient DNA is telling us more and more about humans and environments long past. Could it also help rescue the future?

Deputy speaker of the Assembly, Steven Aiken, has spoken out about the importance of early screening for the ‘Celtic Curse’ – ...

Olaparib plus abiraterone improved survival vs placebo in BRCA-mutated metastatic castration-resistant prostate cancer.

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

Monoallelic loss of PTEN and ARID1A is identified in normal colonic epithelium. The resulting haploinsufficient phenotypes ...

More than a year after a massive great white shark washed ashore in southwestern ... sparked speculation. Now, DNA analysis has revealed that orcas and broadnose sevengill sharks were involved ...

1Division of Cancer Genome Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and National Center for Tumor Diseases (NCT), Heidelberg, Germany 2German Center for Lung ...

mumc.nl Background Severe, disease-causing germline mitochondrial (mt)DNA mutations are maternally inherited or arise de novo. Strategies to prevent transmission are generally available, but depend on ...

We propose that an extended analysis of all coding regions of the UBA1 gene may uncover other mutations with putative functional consequences. References [1]Beck DB, et al. Somatic Mutations in UBA1 ...

Background While p53 mutations occur early ... rather than progressing through metaplasia. In vitro, p53 mutation enhanced BE progenitors’ organoid-forming efficiency, growth, DNA damage resistance ...

While some mutations can introduce premature termination codons (PTCs) into genes, nonsense mediated decay (NMD) can detect these PTCs and then eliminate the abnormal transcripts. PTCs and NMD play ...

Over a year after a 15-foot great white shark was found dead with mysterious bite wounds and stripped of its internal organs, DNA analysis uncovered its killers. Two animals, orcas, also known as ...