This study is led by Professor Jianqiang Bao's research team from Center for Reproduction and Genetics, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of ...

A bacterial expression vector pMALc2-DMRT1 (130-336) was constructed by inserting the region encoding residues from 130 to 336 of X. laevis DMRT1.L into pMAL-c2 (New England Biolabs). The recombinant ...

Differences in sex development (DSD) encompass a range of rare conditions that impact genes, hormones, and reproductive organs, including genitalia. These conditions lead to variations in sex ...

Transcriptome analyses throughout gonadal development, corroborated by qPCR and FISH, validated the significant role of the dmrt1 gene in the sex differentiation of male and female gonads in the ...

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Dujardin et al. observed that chromosomally-male rabbits lacking DMRT1 developed ovaries instead of testes, showing that in rabbits, both SRY and DMRT1 are both required to produce testes.

SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China ...

Other vertebrates use a dosage difference of a single gene. In birds, males have two copies of a Z chromosome with the sex-determining gene DMRT1. Females have a single Z and a W chromosome that lacks ...

In birds, males have two copies of a Z chromosome with the sex-determining gene DMRT1. Females have a single Z and a W chromosome that lacks DMRT1. Sex depends on DMRT1 dosage: two copies in ZZ ...

Ki Aston completed his Ph.D. at Utah State University in 2007. For his dissertation research he evaluated factors associated with somatic cell nuclear transfer efficiency and nuclear reprogramming. He ...

Forkhead transcription factor 2 (Foxl2) and doublesex and mab-3-related transcription factor 1 (Dmrt1) have been proved to be the key factors in fish gonadal differentiation. Foxl2 is one of the ...