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These PROTAC candidates possessed different linker configurations, and PROTAC 8 was able to cause BRD4 degradation in cells, with a half-maximal degradation concentration (DC50) of 80 nM. The authors ...

aInflammation and Immune-Mediated Diseases Laboratory of Anhui Province, The Key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Anhui Institute of Innovative Drugs, School ...

Ubix Therapeutics Co., Ltd., Seoul, Republic of Korea.

Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, Dundee DD1 5JJ, U.K. Centre for Targeted Protein Degradation, School of Life Sciences, ...

The U.S. Environmental Protection Agency’s (EPA) Risk Management Program (RMP) regulations, 40 C.F.R. Part 68, appear to be headed back to rulemaking. These much-debated provisions have been ...

This study by Wu et al. provides valuable computational insights into PROTAC-related protein complexes, focusing on linker roles, protein-protein interaction stability, and lysine residue ...

A vacuum arc discharge was formed at currents of DC30 A and DC50 A. The IGBT was used to commutate the arc current to IGBT to make free-recovery state, which is fundamental transient state for ...

An illustration of a magnifying glass. An illustration of a magnifying glass.