Our findings provide new insights regarding bile acid kinetics and suggest that bariatric surgery in humans alters bile acid profiles leading to activation of FXR and TGR5, which may contribute to ...

Our study shows direct evidence for the in utero effects of perfluoroalkyl exposure on specific key hepatic products. Our results provide evidence that perfluoroalkyl exposure, with potential future ...

Quantitative PCR was performed for genes involved in the FXR pathway (FXR, SHP, BSEP, CYP7A1 and CYP8B1), lipid and cholesterol metabolism (FAS, SREBF, ACACA, PPARg, SCD1, LDLr and HMG-CoA reductase).

Melanocortin 1 receptor (MC1-R) deficiency in hepatocytes increases cholesterol levels in the circulation and liver in mice, while selective activation of MC1-R reduces cellular cholesterol content in ...

Fibroblast growth factor 21 blocks hepatic lipid influx and accumulation, prevents Kupffer cell activation, and inhibits the formation of hepatic lipid- and scar-associated macrophages, thereby likely ...

Dr Roshni R Singaraja, Assistant Professor, Department of Medicine and Cardiovascular Research Institute, NUS Medicine, and co-lead investigator of the study said: "Since the CYP8B1 mutations in our ...

A study team from Singapore General Hospital (SGH) and Yong Loo Lin School of Medicine at National University of Singapore (NUS Medicine) found that pre-clinical models without the CYP8B1 gene ...

FIGURE 1. The synthesis and enterohepatic circulation of LCA. Cholesterol is converted into primary BAs (CA and CDCA) under the action of CYP7A1, CYP27A1, CYP8B1 and related enzymes in hepatocytes.

We found that GPs increased the hepatic expression of the enzymes Cyp7a1, Cyp7b1, and Cyp8b1, which enhanced BA synthesis and cholesterol catabolism. Consistent with these findings, the levels of ...

Insulin, by inhibiting FoxO1 in the liver, reduces 12α-hydroxylated bile acids, cholesterol absorption, and plasma cholesterol levels. Thus, type 1 diabetes leads to a unique set of derangements in ...