In conclusion, human genetic variation of the CYP450 superfamily showed significant ethnic differences, mostly due to population demographic history but also due to adaptation processes. Our study ...

Reduction of plasma cholesterol levels using cholesterol synthesis and/or absorption inhibitors such as statins and ezetimibe, respectively, or induction of CYP7B1 would specifically reduce the ...

In the biomedical field, current technology allows for the collection of multiple data modalities from the same subject. In consequence, there is an increasing interest for methods to analyze ...

Use of stable isotope-labeled full-length proteins as an internal standard prior to multiple reaction monitoring (MRM) analysis enables prefractionation of the target proteins and quantification of ...

Currently we do not know how to reconcile this data other than indicating a potential ER-independent mechanism. Nonetheless, we confirmed the known sex differences in BA synthesis, such as a ...

Specifically, significant upregulation of Cyp7b1 and downregulation of Cyp7a1 were observed, indicating an HDCA-mediated shift from the classic bile acid synthesis pathway to an alternative pathway.

Schematic figure of the role of GPR183 in the immune response to SARS789 CoV-2 and IAV infections. SARS-CoV-2 and IAV infections lead to the upregulation of CH25H and CYP7B1 which results in the ...

Rare SARM1 alleles encoding SARM1 variants that have constitutively high NADase activity and sensitise cultured neurons to mild stress are risk alleles for ALS and other, related motor disorders.

MicroRNA-10a-3p Improves Cartilage Degeneration by Regulating CH25H-CYP7B1-RORα Mediated Cholesterol Metabolism in Knee Osteoarthritis Rats ...

Background: The purpose of this study was to investigate cytochrome P450-7B1 (CYP7B1) in the human and rat testes to regulate 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) activity. We hypothesized ...

CYP7B1/oxysterol 7α-hydroxylase metabolizes 27-hydroxycholesterol to 7α, 27-dihydroxycholesterol, 34 and 27-hydroxycholesterol has been shown to potently exacerbate atherosclerosis progression. 35, 36 ...