Surgery is closely associated with long-term neurocognitive impairment, a condition also known as postoperative neurocognitive disorders. Our translational project explores mechanisms, pathophysiology ...

Finally CYP2W1 only was detected in one sample belonging to the youngest patient. These data show that a range of CYP enzymes are expressed in the skeletal muscle of children and adolescents, ...

A library of duocarmycin bioprecursors based on the CPI and CBI scaffolds was synthesized and used to probe selective activation by cells expressing CYP1A1 and 2W1, CYPs known to be expressed in high ...

AbstractBackground:. An increased risk of neurocognitive deficits, anxiety, and depression has been reported in childhood cancer survivors.Methods:. We analyzed associations of neurocognitive deficits ...

Introduction In the United States, opioid use disorder (OUD) is on the rise among women of reproductive age and is a major health problem. Infants exposed to opioids during pregnancy are likely to ...

In ACC patients treated with mitotane only, high CYP2W1 immunoreactivity adjusted for ENSAT stage was associated with longer overall survival and time to progression (P<0.05 and P<0.01, respectively), ...

150. Altieri B, Sbiera S, Herterich S, De Francia S, Della Casa S, Calabrese A, et al. Effects of Germline CYP2W1*6 and CYP2B6*6 Single Nucleotide Polymorphisms on Mitotane Treatment in Adrenocortical ...

Accordingly, CYP2W1 immunoreactivity was absent/low (H-score 0-1) in 72% of non-adrenal normal tissues, but high (H-score 2-3) in 44% of non-adrenal cancers, in 65% of normal adrenal glands, in 62% of ...

They analyzed and compared the expression of CYP2A6, CYP2B6, CYP2D6, CYP2E1, CYP2J2, CYP2S1, CYP2U1 and CYP2W1 proteins in PFC and AMG samples from alcoholic smokers, alcoholic non-smokers, non ...

They analyzed and compared the expression of CYP2A6, CYP2B6, CYP2D6, CYP2E1, CYP2J2, CYP2S1, CYP2U1 and CYP2W1 proteins in PFC and AMG samples from alcoholic smokers, alcoholic non-smokers, non ...