Homology models of cytochrome P450 26A1 and cytochrome P450 26B1 were constructed using the crystal structures of human, CYP2C8, CYP2C9, and CYP3A4 as templates for the model building. The homology ...

Mapping the Allosteric Action of Antagonists A740003 and A438079 Reveals a Role for the Left Flipper in Ligand Sensitivity at P2X7 Receptors. Cooperative Regulation of Intestinal UDP ...

Cytochrome P450 CYP26 enzymes are responsible for all-trans-retinoic acid (atRA) clearance. Inhibition of CYP26 enzymes will increase endogenous atRA concentrations and is an attractive therapeutic ...

Figure 1. β-carotene accelerates atherosclerosis resolution in wild-type mice infused with anti-sense oligonucleotide targeting the low-density lipoprotein receptor (ASO-LDLR). (A) Four-week-old male ...

Natriuretic peptide signaling has been implicated in a broad range of physiological processes, regulating blood volume and pressure, ventricular hypertrophy, fat metabolism, and long bone growth. Here ...

Introduction Cobia (Rachycentron canadum) is a tropical aquaculture species with high potential due to fast growth rate, high flesh quality, high survival rates, and ease of spawning and larviculture ...

Each vertebrate species appears to have a unique timing mechanism for forming somites along the vertebral column, and the process in human remains poorly understood at the molecular level due to ...

1 Department of Anatomy and Cell Biology, The George Washington University School of Medicine and Health Sciences, Washington, D.C., DC, United States 2 Department of Biology, State College, Penn ...