Homology models of cytochrome P450 26A1 and cytochrome P450 26B1 were constructed using the crystal structures of human, CYP2C8, CYP2C9, and CYP3A4 as templates for the model building. The homology ...

The enzymes and genes involved in RA synthesis, including retinaldehyde dehydrogenase 1 (RALDH1), RALDH2, and RALDH3, RA degradation, such as CYP26A1 and CYP26B1, and RA response, including ...

The changes in RORA, Cyp26a1, Cyp26b1, RARA and Stat3 were statistically significant (p<0.05). Changes in protein expression of ALDH1a1, RARA and RARG supported the gene expression changes.

Cytochrome P450 CYP26 enzymes are responsible for all-trans-retinoic acid (atRA) clearance. Inhibition of CYP26 enzymes will increase endogenous atRA concentrations and is an attractive therapeutic ...

Actually, Cyp26a1 or c1 were not expressed in our mBMDMs (data not shown). Unlike the M2 marker arginase 1, Cyp26b1 did not respond to IL-4 (Figure iA). Hence, Cyp26b1 is an adequate marker to ...

New Target: CYP26A1 enzyme “To restore retinoid-induced differentiation and reduce stem cell numbers, CYP26A1 levels will need to be lowered by inhibiting WNT signaling so that cells can respond to ...

Cytochrome P450 hydroxylase A1 (CYP26A1) was found to be targeted by the Wnt/β-catenin pathway and significantly upregulated in Clmp null tumors. CYP26A1 is the key enzyme that degrades retinoic acid ...

Retinoic acid metabolism by RDH5, RURB, CYP26A1.SIX6, PRSS56, CHD7, ZBTB38, ZIC2, 70BMP4, DLX1 genes involves in the development of the eyes.

A gene expression-based screening assay using chimeric mice with humanized hepatocytes revealed that letrozole has a modifying effect on fibrosis-related gene expression in the hepatocytes ...