The rete ovarii (RO) is an appendage of the ovary that has been given little attention. Although the RO appears in drawings of the ovary in early versions of Gray’s Anatomy, it disappeared from recent ...

Unlike other primary or immortalized kidney proximal tubule cells, aProximate TM PTCs maintain high expression of key transporters like Megalin and Cubilin, making them ideal for drug transporter ...

Megalin and Cubilin are important uptake transporters of siRNA and oligonucleotides in the proximal tubule. They also carry large molecules like albumin, insulin, and aminoglycosides. aProximate ...

The multi ligand receptors megalin and cubilin play pivotal roles in the endocytic uptake of normally filtered proteins in PT cells but also contribute to the uptake of nephrotoxic drugs, including ...

This study aimed to investigate the potential of the cubilin/myeloperoxidase (CUBN/MPO) ratio as a high-grade T1 bladder cancer biomarker. Urine samples were collected from 30 patients who underwent ...

The proximal tubules are the major site of protein and peptide endocytosis of the glomerular filtrate, and cubilin is the proximal tubule brush border membrane glycoprotein receptor that binds ...

The importance of vitamin D and its metabolism to maternal and fetal outcomes is well recognized. Both mother and fetus (in terms of skeletal development and birth weight) are heavily dependent on ...

However, tissues expressing the megalin/cubilin complex, such as the kidney, have the capability of taking up 25(OH)D still bound to DBP, but most tissues rely on the free level. Attempts to calculate ...

In patients with diabetic kidney disease (DKD), plasma renin activity is usually decreased, but there is limited information on urinary renin and its origin. Urinary renin was evaluated in samples ...