Objective Inherited ataxias are heterogeneous disorders affecting both children and adults. The primary cause can be identified in about half of the patients and only very few can receive causative ...

School of Life Sciences, University of Warwick, Coventry, CV4 7AL, U.K. School of Life Sciences, University of Warwick, Coventry, CV4 7AL, U.K. Leicester Medical ...

Center for Precision Disease Modeling, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA Division of Endocrinology, Diabetes and Nutrition, Department of ...

Moreover, 8 pivotal genes were acquired via two machine-learning algorithms. Subsequently, 3 biomarkers related to lactate metabolism were obtained, including COQ2, COQ4, and NDUFV1. And these three ...

Several knockdowns associated with complex I (TMEM261, NDUFA8, GRSF1, and NDUFAF1) and CoQ10 biosynthesis (PDSS1, PDSS2, COQ5, and COQ2) robustly increase mitochondrial or cytosolic ROS.

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Coenzyme Q (CoQ) is essential for ...

Discussion: These findings suggest that the three key lactate metabolism genes, MPC1, COQ2, and ADAMTS13, may serve as effective prognostic biomarkers and support the link between lactate metabolism ...

fDepartment of Neurology, National Center Hospital, National Center of Neurology and Psychiatry (NCNP), Kodaira, Japan gDepartment of Neurology and Neurological Science, Graduate School of Medical and ...

The study, published in e-Life, an online journal for the life-sciences, was co-led by Gustavo Salinas, a professor at Universidad de la República in Uruguay, and Jennifer Shepherd, a professor at ...

In their previous study, Fraser’s team uncovered that UQ and RQ are made from different precursor molecules by the same enzyme called COQ2. But how does COQ2 know to use the UQ precursor when ...

In their previous study, Fraser's team uncovered that UQ and RQ are made from different precursor molecules by the same enzyme called COQ2. But how does COQ2 know to use the UQ precursor when ...