Anti-CD20 mAbs were originally created to treat B cell proliferative diseases such as non-Hodgkin's lymphoma and chronic ...

In particular, targeting a highly expressed BBB-receptor known as transferring receptor ((TfR)), thus activating the receptor mediated transcytosis (i.e., receptor mediated BBB-crossing ...

CRIg, CR3, and CR4 facilitate phagocytosis and modulate the activation state ... complement can revolutionize the treatment of patients with overactive complement-mediated diseases. The authors ...

Eucalyptus leaves have shown potential in treating respiratory diseases and alleviating stress. Research indicates that compounds in eucalyptus may help reduce the risk of cancer, diabetes, and ...

Researchers identify a new player in human immunity that can go rogue and turn the immune system against the body’s own ...

Wu and colleagues confirmed that cultured-microglia-carrying lipid droplets struggled with phagocytosis, poorly engulfing ...

This important study focused on characterizing clonally derived MSC populations from the synovium of normal and osteoarthritis (OA) patients, demonstrating their potential to regenerate cartilage in ...

By targeting surface markers on cancer cells, engineered synthetic receptors expressed on immune cells can be directed to ...

Lastly, we show that bispecific, monovalent IgG4 resulting from Fab arm exchange is a less potent activator of complement than monospecific IgG4. Taken together, these results imply that involvement ...

Laboratoire de Biologie et Modélisation de la Cellule, CNRS, UMR 5239, Inserm, U1293, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, 46 Allée d’Italie, 69364 Lyon, France Centre ...