The method can effectively separate several pairs of normal and variant Hb subunits with mass shifts of less than 1 Da and accurately identify them in intact-protein and top-down analyses. A joint ...

This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...

Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, #06-01 Centros, Singapore 138668, Singapore ...

Compartments organize into big TADs (∼Mb) and smaller loops (∼kb). Loops form by the extrusion of chromatin through the cohesin ring (in green) which finally stalls at CTCF anchoring points (in orange ...

Our findings establish the requirement for cohesin in proper gene expression in specific cell types and implicate defective myelination as a potential contributing factor to cohesinopathy.

SMC complexes, such as condensin or cohesin, organize chromatin throughout the cell cycle ... A LEF is comprised of two subunits, which can either be active or inactive. Each active subunit can ...

Mouse models of shRNA-mediated knock-down of different cohesin subunits developed similar, but not identical alterations in stem cell compartments (30). In the bone marrow there was a marked increase ...