Among them, Cdc25C, CyclinB1 and Cdc2 are crucial regulators at G2/M phase. Following treatment with TAIII, expressions of Cdc25C, CyclinB1, and Cdc2 were all decreased in concentration- and ...

Specifically, the MC-LR and ctHBx-induced changes in the cell cycle-related target proteins cdc2, cdc25C and p53, which are downstream of the MAPK pathway of PP2A, were explored. The results of this ...

Cell division cycle 25c (CDC25c) is a gene coding a phosphatase controlling entry into mitosis upon activation through Polo-like kinase 1 (PLK1) and serves as a key regulator of cell division. The ...

Furthermore, the subsequent sambutoxin-induced activation of ATM and Chk2 resulted in G2/M arrest, accompanied by decreased expression of cdc25C, cdc2, and cyclin B1. Sambutoxin induced apoptosis by ...

In this study, we examined the functional relationship between Cdc25C and ASK1 and identified a novel function of Cdc25C phosphatase that can dephosphorylate and inhibit ASK1 in interphase but not ...

However, ATO decreases cdc25c, which helps sensitize cells to lenalidomide effects enhancing the efficacy of their interaction. Mechanistically the combination of these two agents decreased the ...

Surprisingly, telomere damage targets the CDC25C phosphatase for proteasome degradation in G2/M. CHK1/CHK2‐dependent phosphorylation of CDC25C at Ser 216 is required for CDC25C nuclear export and ...

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Cdk1 activity is controlled by the Cdc25C phosphatase, which is turned on at the G 2 /M transition to catalyze Cdk1 activation. PP2A:B56δ is a negative regulator of Cdc25C during interphase. We show ...

The protein phosphatase Cdc25C, an activator of MPF, enters the nucleus to keep MPF active in the nucleus during prophase. However, the molecular mechanisms that control nuclear translocation of ...