Role of p38 and JNK MAPK signaling pathways and tumor suppressor p53 on induction of apoptosis in response to Ad-eIF5A1 in A549 lung cancer cells. Hellebrin and its aglycone form hellebrigenin ...

The SLC3A2 gene encodes for a cell-surface transmembrane protein CD98hc (4F2). CD98hc serves as a chaperone for LAT1 (SLC7A5), LAT2 (SLC7A8), y + LAT1 (SLC7A7), y + LAT2 (SLC7A6), xCT (SLC7A11) and ...

Because CD98hc participates in integrin signaling and regulates rapid cell proliferation, we hypothesized a role for endothelial CD98hc in pathological and developmental angiogenesis. We tested this ...

SOUTH SAN FRANCISCO, Calif., Aug. 07, 2024 (GLOBE NEWSWIRE) -- Alector, Inc. (Nasdaq: ALEC), a clinical-stage biotechnology company pioneering immuno-neurology, today reported second quarter 2024 ...

In July, Denali posted the manuscript titled, "Fc-engineered large molecules targeting the blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral ...

With the program back, Denali hopes to advance a TfR-targeting ATV:Abeta molecule and a CD98hc-targeting ATV:Abeta molecule into development for Alzheimer’s, according to the release.

These data are included in a recent manuscript posted on bioRxiv. Denali plans to advance a TfR-targeting ATV:Abeta molecule as well as a CD98hc-targeting ATV:Abeta molecule into development for ...

Announced the second TV platform, which targets CD98 heavy chain (CD98hc), an amino acid transporter expressed at the BBB. The CD98hc-targeting TV platform, having distinct properties from Denali ...

Announced the second TV platform, which targets CD98 heavy chain (CD98hc), an amino acid transporter expressed at the BBB. The CD98hc-targeting TV platform, having distinct properties from Denali's ...

2023 Development of a preclinical CD98HC mouse model for therapeutic studies Poster number: 13 Date: November 3rd, 2023 Generation and validation of humanized GARP/TGFB1 mice for testing novel ...

In a recent study published in Nature Communications, researchers engineered and characterized a blood-brain barrier (BBB) transport vehicle targeting the CD98 heavy chain (CD98hc, 4F2 ...