Quantitative measurements of intra-Golgi transport kinetics of diverse secretory cargos challenge the classic cisternal progression model and support the stable compartment model of the Golgi.

Background A rise in paediatric cases of acute hepatitis of unknown origin (AHUO) was observed in 2022, some requiring liver transplantation. A link to adeno-associated virus 2 infection and ...

Eight days post-infection (dpi) with LCMV-Armstrong, the proportions, and numbers of antigen-experienced Tet1/3 cDKO CD8 T cells, as assessed by low CD8a and positive CD11a expression, were modestly ...

Subcutaneous infection by lymphocytic choriomeningitis virus (LCMV) is characterized by skewed CD4 + T-cell polarization, as well as severely impaired differentiation of T follicular helper (T FH) ...

Nanostructured lipid carriers based mRNA vaccine leads to a T cell–inflamed tumour microenvironment favourable for improving PD-1/PD-L1 blocking therapy and long-term immunity in a cold tumour model ...

Downregulation of Sema4A in keratinocytes induces psoriatic non-lesional features, with its signaling cascades potentially triggering psoriasis and serving as targets for treatment and prevention.

Stem cells with high plasticity possess the potential to repair damaged tissue by differentiating into constituent tissue-specific cell types. Stem cells used in current cell-based therapies either ...

Combined variance of T RM markers, CD8A, CD44, and CD103 yielded the indicated areas under the curve (AUC) in Receiver Operating Characteristic (ROC) plots of T cell-high and T cell-low samples from a ...

Idiopathic inflammatory myopathies are a group of autoimmune diseases with a broad spectrum of clinical presentations, primarily characterised by immune-mediated muscle injury. Until recently, there ...