This mutation leads to the production of a defective protein called CD18, preventing leukocytes from traveling to infection sites and effectively fighting infections. Without treatment ...

Without treatment, they rarely live past two years old. The disease is caused by genetic variants in the gene responsible for the production of CD18. CD18 is a protein on the surface of white blood ...

LAD-1 is an inherited genetic disease. It causes a mutation in the gene ITGB2, which is responsible for making a protein called CD18, which is found on the surface of a specific subset of white ...

LAD-1 is an inherited genetic disease. It causes a mutation in the gene ITGB2, which is responsible for making a protein called CD18, which is found on the surface of a specific subset of white ...

A four-year-old boy with an ultra-rare immune disease that is usually fatal before the age of two is living a normal life after taking part in a groundbreaking medical trial that "saved his life".

It causes a mutation in the gene ITGB2, which is responsible for making a protein called CD18, which is found on the surface of a specific subset of white blood cells called neutrophils.

A four-year-old boy with a life-threatening immune disease is now living a normal life thanks to a pioneering gene therapy ...

The β 2 common integrin subunit CD18 is essential for leukocyte–endothelial adhesion and extravasation to inflamed or infected tissue. Damaging variants in ITGB2, which encodes CD18 ...

It is caused by mutations in the gene that produces CD18, a protein that enables white blood cells to travel from the bloodstream to infection sites. In the absence of this critical protein ...

This disease prevents leukocytes from adhering to endothelial surfaces at the sites of inflammation because of a gene mutation encoding CD18. Ultimately, this leads to poor wound healing and ...