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The Lancet1y
Epigenetic activation of O-linked β-N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia
aUniversity Hospital Tübingen, Dept. of Hematology, Oncology, clinical Immunology and Rheumatology, Otfried-Müller-Straße 10, BB West, Rooms 585-587, 72076 Tübingen, Germany ...
The Lancet1y
An HBV susceptibility variant of KNG1 modulates the therapeutic effects of interferons α and λ1 in HBV infection by promoting MAVS lysosomal degradation
aState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of ...
The EMBO Journal3y
ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The metabolic mechanisms driving hematopoietic ...
Medscape3y
Core Binding Factor (CBF) Primary Acute Myeloid Leukemia: Biology and Clinical Implications
Dr. Marcucci is Assistant Professor of Medicine, Division of Hematology-Oncology, Department of Internal Medicine, and The Comprehensive Cancer Center, The Ohio State University College of ...
Frontiers3y
Haploidentical Stem Cell Transplantation for Acute Myeloid Leukemia: Current Therapies, Challenges and Future Prospective
Haploidentical stem cell transplantation (haplo-SCT), an alternative donor source, offers a curative therapy for patients with acute myeloid leukemia (AML) who are transplant candidates. Advances in ...
archive3y
Resonant_Therapy-Molecular_Biology_54
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Frontiers3y
STAT3-Dependent Gene TRIM5γ Interacts With HBx Through a Zinc Binding Site on the BBox Domain
Owing to its broad-spectrum antivirus activities, interferon (IFN) is an important alternative agent for use in the treatment of hepatitis B virus (HBV)-infected patients; however, the mechanism ...
eLife4y
EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice
The male germ cells must adopt the correct morphology at each differentiation stage for proper spermatogenesis. The spermatogonia regulates its differentiation state by its own migration. The male ...
ahajournals.org4y
Arteriosclerosis, Thrombosis, and Vascular Biology
Despite successful therapeutic strategies in the prevention and treatment of arteriosclerosis, the cardiovascular complications remain a major clinical and societal issue worldwide. Increased vascular ...
The EMBO Journal4y
Interactions between lineage‐associated transcription factors govern haematopoietic progenitor states
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Principles of gene regulation underlying ...
ahajournals.org4y
Signalosome-Regulated Serum Response Factor Phosphorylation Determining Myocyte Growth in Width Versus Length as a Therapeutic Target for Heart Failure
Concentric and eccentric cardiac hypertrophy are associated with pressure and volume overload, respectively, in cardiovascular disease both conferring an increased risk of heart failure. These ...
PNAS9y
Aurora kinase-induced phosphorylation excludes transcription factor RUNX from the chromatin to facilitate proper mitotic progression
We thank Valerie Sin Wen Oh and Han Lei Goh for technical assistance. The p14 ARF promoter was a kind gift from Scott Hiebert. This work was supported by the National Research Foundation Singapore, ...