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“The Wnt/β-catenin signaling pathway is one of the most frequently activated oncogenic pathways and a well-described driver of many cancers, but this target had been frustratingly beyond ...

These risk factors should probably include abnormal beta-catenin expression, say a team of researchers from Stanford University, California. Beta-catenin is an intracellular protein involved in ...

In a paper, entitled "GATA3 mediates nonclassical β-catenin signaling in skeletal cell fate determination and ectopic chondrogenesis," co-first authors Takamitsu Maruyama and Daigaku Hasegawa ...

Wnt/β-catenin signaling is a delicate and complex signal transduction pathway mediated by multiple signaling molecules, which plays a significant role in regulating human physiology and pathology.

Dysregulation of the Wnt/β-catenin signaling pathway has been shown to occur in at least 20% of all human cancers. In biochemical and cellular studies, FOG-001 has been shown to potently ...

The process of tubular EMT is governed by multiple intracellular pathways, among which Wnt/β-catenin signaling is considered to be essential mainly because it controls the transcriptome associated ...

Cell-cell and cell-matrix junctions transmit mechanical forces during tissue morphogenesis and homeostasis. α-Catenin links cell-cell adhesion complexes to the actin cytoskeleton, and mechanical load ...

Tau acetylates β‐catenin at K49, which stabilizes β‐catenin by inhibiting its phosphorylation and ubiquitination‐associated proteolysis. β‐catenin mediates the anti‐apoptotic effects of Tau by ...

Specifically, we discovered that these helical mimetics can structurally and functionally mimic the B Cell Lymphoma 9 (BCL9) helix and disrupt cancer-related β-catenin/BCL9 protein–protein interaction ...