MALT1 is the active subunit of the CBM complex that is formed upon receptor activation. The CBM complex consists of multiple subunits of three proteins: CARD11 (caspase recruitment domain family ...

Our study is based on clinical observations that patients with germline gain-of-function (GOF) mutations in CARD11, a known regulator of lymphocyte signaling, frequently develop HLH. Using mouse ...

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is a key regulator of physiological antigen receptor signaling in B cells and T cells, as it is the only component of the ...

In an article published Feb. 7 in Nature, scientists from Northwestern University and the University of San Francisco (UCSF) showed that a cancerous mutation that fuses a pair of genes ...

Various molecular and genetic mechanisms contribute to the transformation of healthy lymphocytes to malignant lymphomas. Gain and loss of genetic material due to various environmental exposures, ...

The authors observed the development of mutations only present in DLBCL after mutation, namely BTG1, BTG2, CARD11, and PIM1. “In conclusion, our data demonstrated temporal and spatial clonal dynamics ...

The following is a summary of “A case of cold agglutinin syndrome associated with chronic lymphocytic leukaemia harbouring mutations in CARD11 and KMT2D.,” published in the May 2023 issue of ...

XL114 hinders the CARD11-BCL10-MALT1 complex, a vital factor of signalling downstream of B- and T-cell receptors, which boosts the survival and proliferation of B- and T-cell lymphoma. Last year, ...

6 The overall five-year survival rate for NHL is 73%. 7 About XL114 XL114 is a novel anti-cancer compound that inhibits the CARD11-BCL10-MALT1 complex, a key component of signaling downstream of B ...

Reporting Feb. 18 in iScience, the researchers focused on the cell biology and genetics of three inherited conditions classified as primary immunodeficiency syndromes, which are caused by mutations in ...