More specifically, the slices were transduced with “AAV9 carrying an HcKCR1 transgene driven by a CAMK2A promoter and a fluorescent tag (enhanced yellow fluorescent protein (eYFP)).” ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Protein quality control serves as the primary ...

LONDON, June 24, 2024--(BUSINESS WIRE)--EpilepsyGTx, a biotechnology company focused on research and development of cutting-edge gene therapies to treat focal refractory epilepsy, today announced ...

EPY201 is an investigational gene therapy targeting focal refractory epilepsy. EPY201 or AAV9-CAMK2A-EKC uses an AAV9 capsid, an engineered Kv1.1 potassium channel (or “EKC”) and a CAMK2A promoter.

UCL researchers have developed a new gene therapy to cure a devastating form of childhood epilepsy, which a new study shows can significantly reduce seizures in mice. The study, published in Brain ...

University of California Oakland and University of Copenhagen scientists have jointly developed calcium/calmodulin-dependent protein kinase type II subunit α (CaMK2A) modulators reported to be useful ...

Rotarians pledged to donate £200 to help buy a buggy for five-year-old Tommy Holmes who suffers from genetic condition CAMK2A which delays growth and causes seizures and intellectual impairment. A ...

Recording calcium transients in CAMK2A- and VGAT-expressing cells in dorsal hippocampal area CA1. (A) Scheme showing mouse with miniaturized microscope to record calcium transients from either ...

Translating ribosome affinity purification was used to profile ribosome-associated RNAs in different subcellular compartments (cytosol and membrane) and in different cell populations (whole ...

1Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, P.R. China. 2Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, ...