The researchers reported in Nature Communications that the PCR-based test and bedside instrument can identify the risk of sepsis within 24 hours.

In the September 20 Nature Communications, scientists led by Andrew Saykin at Indiana University School of Medicine, Indianapolis, reported that a risk variant of CYP1B1, a member of the cytochrome ...

What were the main findings of this study? This study identified the enzyme CYP1B1 as a biomarker and predictor of HSC activation and liver fibrosis in both patients and mice. Inhibition of CYP1B1 ...

This study identified the enzyme CYP1B1 as a biomarker and predictor of HSC activation and liver fibrosis in both patients and mice. Inhibition of CYP1B1 led to the accumulation of a sugar called ...

Investigators found that the use of oral contraceptives (OCs) may be associated with an increased risk for frontal fibrosing alopecia (FFA) in women with a common variant in the CYP1B1 gene.

AHR also regulates the expression of CYP1A1, CYP1A2 and CYP1B1, which catalyze the metabolism of polycyclic aromatic hydrocarbons and other aromatic compounds. The present application describes a ...

CYP1A1 and CYP1A2 exhibit catalytic activity predominantly for the 2-hydroxylation of estradiol, whereas CYP1B1 exhibits catalytic activity predominantly for 4-hydroxylation of estradiol. To ...

Congenital glaucoma describes a rare group of diseases that affect the eyes from birth. When a newborn has glaucoma, the fluid in the eye does not drain properly, placing pressure on the optic ...

It is converted into a toxic compound by the P450 CYP1B1 enzyme, found in much higher levels in cancer cells. As a result, the researchers found, it proved to be 20 times more toxic to cancer cells ...

Mechanistically, activation of the AhR typically results in upregulation of the cytochrome P450 (CYP1) members cyp1a1, cyp1a2 and cyp1b1 (1). CYP enzymes are monooxygenases that catalyze various ...