Pharmaceutical and Medicinal Chemistry (Computer-Aided Drug Design), Institute of Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany Department of Pharmaceutical Sciences, Division of ...

Objective: To assess the genotypic and allelic distribution of the rs10046 polymorphism in the CYP19A1 gene and evaluate whether this aromatase gene variant is associated with cardiovascular risk in ...

Genetic variation affecting function of the aromatase gene (CYP19A1) has been linked to elevated estradiol levels. We tested the hypothesis that these variants, as well as a modifying gene, are ...

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This appears to be part of the autism puzzle," she said. Brain aromatase, encoded by CYP19A1, converts neural androgens to neural estrogens and has been implicated in ASD. Postmortem analyses of ...

In fact, one variant in the CYP19A1 gene, which is involved in the aromatization of testosterone to estradiol, has been positively associated with estradiol concentrations and postmenopausal ...

In untreated women with CAH, the excess of estrogen results from androgen aromatization. Studies showed that in such patients, both aromatase (CYP19A1) and 17β-hydroxysteroid dehydrogenase type I ...

In the mid-1900s, scientists used the aromatase enzyme (CYP19A1) to catalyze androgens to synthesize estrogens, which ultimately led to the development of aromatase inhibitors. Concurrently ...

CYP19A1 plays a key role in testosterone metabolism. Lung samples analyzed from deceased COVID-19 patients also showed increased expression of the CYP19A1 gene in male patients compared to female ...

In the DGHM symposium on infection immunology, Stephanie Stanelle-Bertram (Leibniz Institute of Virology, Hamburg, Germany) presented the data of 2866 patients with COVID-19 in which the study group ...