Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. This longitudinal single-cell transcriptome ...

Department of Pathogenic Biology, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China ...

Background Single cell sequencings studies have identified a CXCL14+ synovial fibroblast cluster in synovial tissue. This CXCL14+ cluster express CD34 and correlate to lower DAS28 and swollen joint ...

The proinflammatory CD11c + macrophages that accumulate in obese adipose tissue express high levels of neutrophil chemotaxis genes resulting in elevated secretion of neutrophil chemotaxis proteins, ...

CXCL14/CpG DNA complex is efficiently transported into dendritic cells. CXCL14/CpG DNA induces cytokine production via Toll-like receptor 9. We discovered that CXCL14 specifically binds CpG DNAs with ...

Conclusions CXCL14 is a systemic biomarker that could be used to identify IPF patients with increased Hh pathway activity and monitor the pharmacodynamic effects of Hh antagonist therapy in IPF. Trial ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. How cells coordinate morphogenetic cues and ...

Chemokines belong to a family of proteins called the cytokines and are involved in initiating and guiding the recruitment and migration of immune cells to sites of infection or damage. Chemokines ...

Different anatomical locations of the body skin show differences in their gene expression patterns depending on different origins, and the inherent heterogeneous information can be maintained in ...

The team focused on Staphylococcus aureus, a common skin-resident pathogen, which grows actively during the daytime in the skin of mice deficient in chemokine CXCL14. Healthy mice usually showed ...