A study from Stanford researchers identifies the CXCL12 gene as a crucial regulator of the posterior descending artery’s development in the human heart. The findings, which link this gene to heart ...

Further analyses using single-cell RNA sequencing and 3D microscopy revealed that the endothelial cells of these vessels express large amounts of the signaling protein CXCL12. Following up on this ...

CXCR7 is a key mediator in signal transduction amplifying fibrosis and inflammation. CXCR7 selectively binds to chemokine ligand CXCL12, targeting various pathways associated with fibrosis, ...

The presentation showed that combining CXCL12 inhibition with anti-PD-1/CTLA4 immune checkpoint inhibition increases the presence of anti-cancer immune cells in tumor tissues both inside and ...

Measuring the levels of a novel protein biomarker called C-X-C motif chemokine ligand 12 — CXCL12 for short — in the spinal fluid may improve the diagnosis of amyotrophic lateral sclerosis (ALS) by ...

Folinic acid enhances that response." PDAC resists immune cells, using a protective shield built from two proteins -- CXCR4 and CXCL12. This defensive wall is virtually impenetrable. But when the ...

The C-X-C motif chemokine ligand 12 (CXCL12) binds to C-X-C chemokine receptor type 4 (CXCR4) and C-X-C chemokine receptor type 7 (CXCR7). The interaction of CXCL12 and its receptors subsequently ...

Background: SDF-1/CXCL12 is a chemokine with pleiotropic functions in hematopoietic stem cell niche homeostasis, germinal center architecture, B cell maturation, neoangiogenesis, and fibrosis.

Here, we show that a chemoattractive CXCL12/CXCR4-dependent mechanism entraps growth-stimulated axons at the lesion site, thereby limiting axon extension in the nerve. Accordingly, specific depletion ...