Northwestern Medicine investigators have developed a new avenue to reprogram compromised immune cells to act against tumors, ...
In December 2023, through the development efforts of CRISPR Therapeutics and Vertex Pharmaceuticals, their decades-long ...
This marks the first successful treatment of its kind ... by Vertex Pharmaceuticals and CRISPR Therapeutics, is the first licensed therapy to utilise CRISPR/Cas9 gene-editing technology, whose ...
Background: Docetaxel remains the standard treatment for metastatic castration-resistant prostate cancer (mCRPC ... AZD8186 were tested in docetaxel-resistant xenograft mice. CRISPR-Cas9 generated a ...
Mounting evidence indicates that tissue mechanics plays a pivotal role in cancer cell and stromal cell behavior ... We further demonstrate that CRISPR/Cas9-engineered human HCC cell lines with ...
We examined the impact of Acod1-deficiency and 4-OI treatment on bone erosion in mice using K/BxN ... in the osteoclast transcriptome were identified by RNA sequencing. CRISPR/Cas9 gene editing was ...
(B) Effects of myriocin treatment on SY1 cytotoxicity in yeast cells as judged ... Generation of HEK293t SPTLC2 knockout cells by CRISPR/Cas9 For the generation of SPTLC2 knockout cell line, guide RNA ...
Scientists are exploring gene editing as a way to correct trisomy at the cellular level. Using CRISPR-Cas9, researchers successfully removed extra copies of chromosome 21 in Down syndrome cell lines, ...
A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...
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