Learn about brittle bone disease, including its causes, symptoms, types, diagnosis, and treatment options to support better ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. This longitudinal single-cell transcriptome ...

Osteogenesis imperfecta (OI) is primarily caused by mutations in the COL1A1 or COL1A2 genes, which leads to a reduction in type 1 collagen production and changes in bone metabolism. This results in ...

Trial results show setrusumab reduces the incidence of fracture and increases bone density and formation. The Food and Drug Administration (FDA) has granted Breakthrough Therapy designation to ...

Osteogenesis imperfecta (OI) is primarily caused by mutations in the COL1A1 or COL1A2 genes, which leads to a reduction in type 1 collagen production and changes in bone metabolism. This results ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Transcriptomic and biochemical analyses of ...

NOVATO, Calif. and LONDON, June 11, 2024 (GLOBE NEWSWIRE) -- Ultragenyx Pharmaceutical Inc. (NASDAQ: RARE) and Mereo BioPharma Group plc (NASDAQ: MREO) today announced positive 14-month results ...

Ligand-receptor analyses demonstrated SFRP4+CAFs regulate key genes of EMT in malignant cells (TGFBI, COL1A1, SPARC, COL3A1, COL1A2, and BGN). The regulatory roles of SFRP4+ CAFs in driving the ...

The method is almost identical to conventional shotgun proteomics analysis of bone samples, except that the database used by the SEQUEST search engine consisted only of entries for collagen type 1 ...