Head and neck squamous cell carcinoma (HNSCC) is distinguished by the absence of definitive diagnostic markers and effective treatment modalities, which results in its poor clinical outcomes. Although ...

CDKN1A may lead to differentiation of normal and transformed cells and suppression of malignant cell growth in vitro and in vivo. 2 Moreover, it may lead to apoptosis involving the tumor protein 53 ...

Circulating tumor DNA (ctDNA) is a novel biomarker to monitor treatment response and predict cancer recurrence. However, the real-world performance of ctDNA monitoring is not well characterized in ...

Calcineurin fine tunes the balance between proliferation and differentiation of Notch-responsive progenitors in the pancreatic ducts to enable beta cell regeneration in zebrafish.

Fibrosis and accumulation of senescent cells are common tissue changes associated with aging. Here, we show that the CDK inhibitor p21 (CDKN1A), known to regulate the cell cycle and the viability of ...

Senescent cells secrete bioreactive molecules that promote disease, fibrosis, and aging, yet the molecular mechanisms driving the production of these secreted factors remain incompletely understood.

To directly determine whether MBNL1 suppresses proliferation by stabilizing Cdkn1a and Gadd45a transcripts, a rescue experiment was performed using the Fluorescent Ubiquitination-Based Cell Cycle ...

Figure 1 CDKN1A and TP53 expression in bone marrow mesenchymal stromal cells from myelodysplastic syndromes, acute myeloid leukemia with myelodysplasia-related changes, de novo acute myeloid leukemia ...

Of those, up-regulations of Cdkn1a and Apaf1 mRNA expression were successfully validated by direct quantification. Moreover, haloperidol and aripiprazole dose-dependent upregulation of both mRNA ...

A SNAI2/CDKN1A pathway protects rhabdomyosarcoma tumors from radiation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited ...