Nervous necrosis virus typically enters host cells via endocytosis, but it can also enter via a process called macropinocytosis.

In vitro, activation of cell division cycle 42 (Cdc42) maintained the morphological characteristics of quiescent HSCs. Cdc42 activation in HSC cell lines inhibited the expression of markers ...

Notably, BBR exerted its phagocytosis effects through targeting phosphoinositide 3-kinase (PI3K), thereby activating the small GTPase-Cdc42 (CDC42), Wiskott-Aldrich syndrome protein (WASP), and ...

In this study, we investigated how actin polymerization and ectocytosis are regulated within the cilium. Our findings reveal that ciliary CDC42, a RHO-family GTPase triggers in situ actin ...

They also found that USP1 inhibits cdc42, increases EWS-FLI1 transcriptional output, and simulates Ewing sarcoma growth. Results show that chemo-sensitization by USP1 is independent of cdc42.

Dedicator of cytokinesis 11 (DOCK11) activates the small Rho guanosine triphosphatase (GTPase) cell division cycle 42 (CDC42), a central regulator of actin cytoskeleton dynamics. The role of ...

This process was enhanced by the presence of several proteins, including the Wiskott-Aldrich syndrome protein (WASP)/N-WASP, WISH, Nck, the activated small GTPase Cdc42, and a membrane-anchored ...

In mice, the Cdc42 gene is necessary for the correct polarity of Sertoli cells that support sperm production, according to a new study. Findings may accelerate efforts to create a non-invasive ...

Aging of hematopoietic stem cells (HSCs) is caused by the elevated activity of the small RhoGTPase Cdc42 and an apolar distribution of proteins. Mechanisms by which Cdc42 activity controls polarity of ...

The Rho family GTPases Rho, Rac, and Cdc42 have emerged as key players in cancer metastasis, due to their essential roles in regulating cell division and actin cytoskeletal rearrangements; and thus, ...